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    Tehran University of Medical Sciences

    Faculty of Pharmacy

     

    Honorary Lecturer


    Prof. Dr. Wolfgang J. Parak

              FachbereichPhysik, Philipps University Marburg, Germany,

    CIC Biomagune, San Sebastian, Spain

     

    “Quantification of Nano-particle Uptake & Degradation by Cells& Its Correlation to Basic Physico-chemical Parameters”

     

    9:00 AM, Sunday, March 06,2016; Razi Hall

    Abstract:

    Some common sense statements about the interaction of colloidal nanoparticles

    with cells are given. While detail of this interaction strongly depends on the precise

    properties of the nanoparticles, the type of cells, conditions of incubation, etc. still some

    basic universal common sense dependences exist, which will be outlined. In general small,

    elongated, positively charged, soft particles are incorporated in vitro by cells to a higher

    extend than big, flat, negatively charged, stiff particles. After in vivo incorporation the

    environment of the nanoparticles drastically changes. In particular the nanoparticle may be

    exposed to different enzymes such as proteases. This may lead to changes in the surface

    chemistry of the nanoparticles. Consequences for active versus passive targeting will be

    discussed.


    Biography:

    Wolfgang J. Parak obtained his Ph.D. at the LMU Mnchen, Germany (1999), in

    the group of Prof. Dr. Hermann Gaub. After a postdoctoral stay at the University of

    California, Berkeley, CA, USA, in the group of Prof. Dr. Paul Alivisatos, he returned to Munich

    in 2002 as Assistant Professor. Since 2007 he has been Full Professor at the Philipps

    Universitt Marburg, Germany. He is now serves as associate editor of ACS Nano.


    TUMS Pharmacy

    Public Relations Dept.

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